Mouse Model for Mesothelioma Reproduces Human Disease

According to an article on mesothelioma research, scientists have established a mouse model for human malignant mesothelioma that will provide valuable insight into cancer development and progression along with new directions for design of therapeutic strategies. The research, published by Cell Press in the March issue of Cancer Cell, may eventually lead to a substantially improved outlook for patients with this devastating disease.

Chemotherapy can sometimes lead to improvement of overall survival but there is no cure for malignant mesothelioma and patients often succumb from the disease within a year of diagnosis. "There is an urgent need for experimental models of malignant mesothelioma that can be used to not only study the onset and progression of the disease, but also to serve as a model to select new combination therapies and targeted agents," says study leader, Dr. Anton Berns, from The Netherlands Cancer Institute.

In humans, malignant mesothelioma has been associated with genetic lesions that result in the loss of Neurofibromatosis type 2 (NF2) and genetic lesions affecting RB and P53 pathways. Dr. Berns' team investigated whether a range of conditional single or compound mutations in the Nf2, p53 and Rb pathways within the mesothelial lining of the thoracic cavity would cause malignant mesothelioma in mice.

The researchers found that the vast majority of mice with conditional Nf2;Ink4a/Arf and Nf2;p53 mutations developed MM after a short latency period. The mouse malignant mesothelioma tumors, which could be followed noninvasively through the use of bioluminescence imaging, closely resembled human MM. Interestingly, Nf2;Ink4a/Arf knockout mice had a more invasive cancer when compared with Nf2;p53 knockout mice. The researchers went on to show that the loss of Ink4a makes a substantial contribution to the poor clinical outcome of murine malignant mesothelioma.

These results describe an excellent model system for investigating the molecular mechanisms that underlie malignant mesothelioma . "Our mouse models should be suitable to further dissect pathways critically important in mesothelioma development and progression and serve as invaluable tools to test new intervention strategies," concludes Dr. Berns. "We have also derived a series of cell lines that reproduce the disease when grafted into the thoracic cavity. These may also facilitate design of better MM therapies."

Inspiring letter from cancer survivor

Here’s an excerpt from an inspiring letter, and valuable advice, from a Mesothelioma survivor. Read the entire letter here.


Dear Fellow Cancer Patient:


I'm Dick Bloch. In March, 1978 I was diagnosed with terminal lung cancer and given 3 months to live by an outstanding doctor. I am now healthy, cancer free, and devoting myself along with my wife, Annette, to helping the next person with cancer have the best chance of beating it. I'm not saying you can have the same success I did, but if you try, you have a chance.

The biggest and the hardest single thing that you will be required to do in the entire battle is to make up your mind to really fight it. You must, on your own, make the commitment that you will do everything in your power to fight your disease. No exceptions. Nothing halfway. Nothing for the sake of ease or convenience. Everything! Nothing short of it. When you have done this, you have accomplished the most difficult thing you will have to accomplish throughout your entire treatment. And I don't care how serious or how minor you are led to believe your cancer is.

Remember, once you have made the commitment, everything else is relatively easy. There will be pleasant experiences. There will be unpleasant experiences. But I can promise you it is not as difficult as making the decision to make the commitment.

Call the Cancer Hot Line at 800-433-0464 to request a copy of Fighting Cancer and to ask for a list of institutions that provide a multidisciplinary second opinion..All of this and much more is yours for the asking.

There is a saying that it takes 6 things to beat cancer. First is the best possible medical treatment. Second is the best possible medical treatment. Third, fourth and fifth are the best medical treatment. Sixth is a positive mental attitude. Without all 6, you don't have a chance. But look at it in that perspective and relative importance. A positive mental attitude is not burying your head in the sand and saying' "I'm going to get well." It is doing everything within your power in addition to medicine to help yourself recover.

That "everything" is to thoroughly read and digest the book, "Fighting Cancer" that you received by calling 800-433-0464. It is written in plain English to help you understand your disease and do everything in your power to help you fight it. The last chapter is a check list.

Fighting cancer is not a simple matter of thinking positively, wishing it away and saying, "Hey, doc, cure me." It is a matter of knowledge. It is a matter of educating yourself about every detail and mustering all your resources. Use every drop of energy in an organized fashion to constructively concentrate on getting rid of cancer. Most cancers can be successfully treated, but generally you have only one chance. If you miss that first chance, if you don't do everything in your power, often there is no second chance.

This is why no cancer patient can afford the luxury of looking back and saying, "I wish I would have...." Never look back. Concentrate on this moment forward and do everything in your power. There is no downside risk. Now you may have a chance.

Good Luck & God Bless You,

Dick Bloch



If you, a coworker or a family member has been exposed to asbestos, contact the law firm of LEVY PHILLIPS & KONIGSBERG, LLP. LPK has been a pioneer in representing victims of asbestos exposure, and is one of the nation’s premier law firms in the areas of toxic torts, product liability, personal injury, and discrimination law.

Cancer Society: Ban Asbestos to Stop Mesothelioma and Asbestos Cancer Death

Canada has long been the world's largest exporter of chrysotile asbestos, which accounts for more than 90% of the asbestos historically used in the United States.

The Canadian government continues to claim that chrysotile asbestos is safe.

Now Canadian cancer experts are taking a stand against this long held government policy which seeks to protect the prized, but deadly, mineral and the profits it brings to Canadian mines and manufacturers.

The Canadian Cancer Society is now calling for an asbestos ban.
http://www.canada.com/topics/news/story.html?id=50d51cc6-b606-4ffd-a1c9-db40c1e8d42b&k=15816

According to this Canada.com article: "The society believes that exposure to asbestos must stop so that asbestos-related diseases can be eliminated," Barbara Whylie, CEO of the Canadian Cancer Society, said in a written statement.

In response, Pat Martin, an MP and former asbestos worker was quoted as saying:

"....it was high time a group as credible as the Canadian Cancer Society 'debunked the myth' that chrysotile asbestos is safer than other types of asbestos."

It is refreshing to see an influential group like the Canadian Cancer Society challenge the Canadian government's irresponsible position that has caused tens of thousands of workers in Canada and the United States to develop mesothelioma and asbestos cancer.

The same propaganda put out by the Canadian government is adopted by American corporations who seek to avoid responsibility for compensating asbestos victims.

Chrysotile asbestos accounts for nearly all the asbestos ever used in the United States and is the greatest contributor to malignant mesothelioma in this country.